Dr. Marcelo César Murguía, Ph.D.

Laboratorio de Química Aplicada (LAQUIMAP), Cátedra de Química Orgánica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.C. 242, Ciudad Universitaria, 3000 Santa Fe, Argentina.

Profesor titular, por concurso, en Química Orgánica de la Universidad Nacional del Litoral.

Investigador Independiente del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET).

Email: mmurguia@fbcb.unl.edu.ar / mmurguia@santafe-conicet.gov.ar 

Keywords: Química Orgánica, Química Fina, Tecnología Química, Biotecnología

2024-02-05

Abstract: In this work we report a detailed study of the transesterification reaction of β-ketoesters in solvent and catalyst-free conditions, using microwave irradiation. Different alcohols, including fatty alcohols, were tested to optimize the reaction conditions. Good yields, without the formation of secondary products, were observed at 150 °C. The compounds obtained were used as starting substrates in a Biginelli-type multicomponent synthesis to obtain long-chain ester monastrol derivatives, at 80 °C, with good yields, and generally free of secondary products.

Title: Solvent and catalysis-free microwave transesterification of β-ketoesters and its application in the production of long-chain ester monastrol derivatives

Authors: Edna X. Aguilera, Ángel G. Sathicq, Daniela I. Lick, Mónica L. Casella, Marcelo C. Murguía, Luis R. Pizzio, Gustavo P. Romanelli

Journal: Sustainable Chemistry and Pharmacy, 37, (2024), 101386